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Table 1 Kinetic parameters for the NS5A:Fyn SH3 domain interaction.

From: Hepatitis C virus NS5A protein binds the SH3 domain of the Fyn tyrosine kinase with high affinity: mutagenic analysis of residues within the SH3 domain that contribute to the interaction

Protein ka (M-1s-1) kd (s-1) KD (M-1)
NS5A(Δ32) 4.93 × 103 3.08 × 10-3 6.29 × 10-7
(± SD) n = 3 (± 0.66 × 103) (± 0.16 × 10-3) (0.59 × 10-7)
NS5A(Δ250) 9.05 × 103 4.94 × 10-3 5.56 × 10-7
(± SD) n = 3 (± 1.62 × 103) (± 0.11 × 10-3) (0.59 × 10-7)