From: Hepatitis C virus NS5A protein binds the SH3 domain of the Fyn tyrosine kinase with high affinity: mutagenic analysis of residues within the SH3 domain that contribute to the interaction
Protein
ka (M-1s-1)
kd (s-1)
KD (M-1)
NS5A(Δ32)
4.93 × 103
3.08 × 10-3
6.29 × 10-7
(± SD) n = 3
(± 0.66 × 103)
(± 0.16 × 10-3)
(0.59 × 10-7)
NS5A(Δ250)
9.05 × 103
4.94 × 10-3
5.56 × 10-7
(± 1.62 × 103)
(± 0.11 × 10-3)