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Table 2 Pathogenicity of G954 MV strains in vivo

From: Wild type measles virus attenuation independent of type I IFN

Mice genotype (no. of mice) Viral strain Mortality rate (time/days) MV replication (10 days pi) (*)   anti-N response (15 days pi)(†)
    brain lung  
C57/Bl6 (8) G954 PBL 0 % - - -
  G954 V13 0 % - - -
CD150 tg (6–8) G954 PBL 100% (9–15 d) +++ + ++
  G954 V13 0% - - +/++
  UV inactivated G954 V13 0% nd nd -
CD150/IFNARKO (8–10) G954 PBL 100% (9–11 d) nd nd nd
  G954 V13 0% nd nd +/++
  1. (*)determined by RT PCR on N mRNA: +++ > 10× housekeeping gene expression; + > 0,1× housekeeping gene expression ; – beyond limit of detection ; nd not determined
  2. (†) determined by ELISA on N specific sera antibodies: ++ between 1 and 10 arbitrary units; + between 0,1 and 1 arbitrary units; – beyond 0,1 arbitrary units