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Table 2 Pathogenicity of G954 MV strains in vivo

From: Wild type measles virus attenuation independent of type I IFN

Mice genotype (no. of mice)

Viral strain

Mortality rate (time/days)

MV replication (10 days pi) (*)

 

anti-N response (15 days pi)(†)

   

brain

lung

 

C57/Bl6 (8)

G954 PBL

0 %

-

-

-

 

G954 V13

0 %

-

-

-

CD150 tg (6–8)

G954 PBL

100% (9–15 d)

+++

+

++

 

G954 V13

0%

-

-

+/++

 

UV inactivated G954 V13

0%

nd

nd

-

CD150/IFNARKO (8–10)

G954 PBL

100% (9–11 d)

nd

nd

nd

 

G954 V13

0%

nd

nd

+/++

  1. (*)determined by RT PCR on N mRNA: +++ > 10× housekeeping gene expression; + > 0,1× housekeeping gene expression ; – beyond limit of detection ; nd not determined
  2. (†) determined by ELISA on N specific sera antibodies: ++ between 1 and 10 arbitrary units; + between 0,1 and 1 arbitrary units; – beyond 0,1 arbitrary units