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Figure 2 | Virology Journal

Figure 2

From: Wild type measles virus attenuation independent of type I IFN

Figure 2

Viral resistance to type I IFN induced protection depends upon the cell type used for viral adaptation. G954-PBL infections of Vero/CD150 cells could be blocked with high doses of type IFN but the efficacy relied on the delay before treatment [(A): 2 hours (C): 12 hours between infection and type I IFN addition]. Infections with G954-V13 were less affected by type I IFN [(B): 2 hours (D): 12 hours between infection and type I IFN addition]. Infection of PBMCs by wt MV was not affected by type I IFN regardless of dose [(E): 2 hours between infection and type I IFN addition]. However, high doses of type I IFN could inhibit the G954-V13 strain infection [(F): 2 hours between infection and type I IFN addition]. Ed-Zagreb infections of both Vero/CD150 cells [(G): 4 hours between infection and type I IFN addition] and PBMCs [(H): 2 hours between infection and type I IFN addition] were relatively unaffected by type I IFN. Cells were infected at a MOI of 0,1 during 2 hours then washed. Various dilutions of type I IFN were added to cell cultures at specified times.

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