Table 4 Differentially regulated Th genes of HepG2 hepatocytes infected with DENV.
From: Molecular profiling of T-helper immune genes during dengue virus infection
Gene | Gene name | Fold Change | Immune cell activation | Inflammatory responses | Thrombo-cytopenia | Vascular permeability |
|---|---|---|---|---|---|---|
Th1 immune response | ||||||
S152/T14 | CD 27 | -2.06 | ✓ | |||
CSF2 | GMCSF | -2.91 | ✓ | ✓ | ✓ | ✓ |
CDw218a/IL-1Rrp | Interleukin 18 receptor 1 | -3.15 | ||||
Tp44 | CD28 | -7.07 | ✓ | |||
CD154/CD40L | CD40 ligand | -9.20 | ✓ | ✓ | ✓ | ✓ |
Th2 immune response | ||||||
AILIM/CD278 | Inducible T-cell co-stimulator | 2.28 | ✓ | |||
CC-CKR-2/CCR2A | Chemokine receptor 2 | 4.08 | ✔ | ✔ | ✔ | |
CC-CKR-3/CD193 | Chemokine receptor 3 | 4.54 | ✔ | ✔ | ||
HP40/IL-9 | Interleukin 9 | -2.49 | ✓ | ✓ | ✓ | |
BSF1/IL-4 | Interleukin 4 | -2.73 | ✓ | ✓ | ✓ | ✓ |
EDF/IL-5 | Interleukin 5 | -7.12 | ✓ | ✓ | ||
Th1\Th2 immune response | ||||||
PTPRC | Protein tyrosine phosphatase, receptor type, C | -3.73 | ✓ | ✓ | ✓ | |
4-1BB/CD137 | Tumor necrosis factor receptor superfamily | -3.41 | ✓ | ✓ | ✓ | |
Transcriptional Factors | ||||||
STAT4 | Signal transducer and activator of transcription 4 | -2.17 | ✓ | ✓ |