Table 3 Differentially regulated Th genes of K562 cells infected with DENV.
From: Molecular profiling of T-helper immune genes during dengue virus infection
Gene | Gene name | Fold Change | Immune cell activation | Inflammatory responses | Thrombo-cytopenia | Vascular permeability |
|---|---|---|---|---|---|---|
Th1 immune response | ||||||
RP11-102M16.1 | Interleukin 12 receptor | 2.01 | ✓ | ✓ | ||
DIF/TNF-alpha | Tumor necrosis factor α | 2.06 | ✔ | ✔ | ||
CC-CKR-5/CCCKR5 | Chemokine receptor 5 | 2.30 | ✔ | ✔ | ||
CSF2 | GMCSF | 2.45 | ✔ | ✔ | ✔ | ✔ |
CD80 | CD28LG/CD28LG1 | 2.60 | ✓ | |||
TLR6 | Toll-like receptor 6 | 6.04 | ✔ | ✔ | ✔ | ✔ |
CD69 | CLEC2C | 14.62 | ✔ | ✔ | ✔ | ✔ |
IL2 | Interleukin 2 | -2.20 | ✔ | ✔ | ✔ | ✔ |
APT1LG1/CD178 | FASLG | -2.48 | ✓ | |||
CLMF/CLMF2 | Interleukin 12B | -3.35 | ✓ | ✓ | ||
CD121b/IL1RB | Interleukin 1 receptor | -3.67 | ✓ | |||
Th2 immune response | ||||||
CC-CKR-2/CCR2A | Chemokine receptor 2 | 2.14 | ✔ | ✔ | ✔ | |
CC-CKR-4/CKR4 | Chemokine receptor 4 | 3.25 | ✔ | ✔ | ✔ | ✔ |
CC-CKR-3/CD193 | Chemokine receptor 3 | 4.44 | ✔ | ✔ | ||
RANTES | Chemokine ligand 5 | 31.78 | ✔ | ✔ | ✔ | ✔ |
BSF1/IL-4 | Interleukin 4 | -2.25 | ✔ | ✔ | ✔ | ✔ |
HDR | GATA binding protein 3 | -2.61 | ✓ | ✓ | ||
IL1RL1LG/Il1rl1l | Transmembrane emp24 protein transport domain | -2.74 | ✓ | |||
AILIM/CD278 | Inducible T-cell co-stimulator | -2.75 | ✓ | |||
CD124/IL4RA | Interleukin 4 receptor | -3.52 | ✓ | ✓ | ||
FIC/MARC | Chemokine ligand 7 | -3.76 | ✓ | ✓ | ✓ | |
Th1\Th2 immune response | ||||||
LAT | Linker for activation of T cells | 4.69 | ✓ | |||
4-1BB/CD137 | Tumor necrosis factor receptor superfamily | 4.98 | ✔ | ✔ | ✔ | |
BSF2/HGF | Interleukin 6 | 6.96 | ✔ | ✔ | ✔ | ✔ |
IL-7 | Interleukin 7 | -2.87 | ✓ | ✓ | ✓ | |
PTPRC | Protein tyrosine phosphatase, receptor type, C | -3.39 | ✓ | ✓ | ✓ | |
Transcriptional Factors | ||||||
SOCS2 | Suppressor of cytokine signaling 2 | 2.27 | ✔ | ✔ | ||
ZNF163 | Growth factor independent 1 | -2.01 | ✓ | ✓ |