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Table 2 Differentially regulated Th genes of Jurkat cells infected with DENV.

From: Molecular profiling of T-helper immune genes during dengue virus infection

Gene

Gene name

Fold Change

Immune cell activation

Inflammatory responses

Thrombo-cytopenia

Vascular permeability

Th1 immune response

      

CSF2

GMCSF

2.08

✔

✔

✔

✔

APT1LG1/CD178

FASLG

2.18

 

✔

  

INHA

Inhibin, alpha

2.19

✓

   

CLMF/CLMF2

Interleukin 12B

2.20

✔

✔

  

CD80

CD28LG/CD28LG1

2.29

✓

   

IFNG

Interferon, gamma

2.85

 

✔

✔

✔

IL18

Interleukin 18

3.69

✔

✔

 

✔

IL2

Interleukin 2

3.97

✔

✔

✔

✔

TLR6

Toll-like receptor 6

8.68

✔

✔

✔

✔

CD182/CD183

CXCR3

-2.12

✓

✓

  

Th2 immune response

      

RANTES

Chemokine ligand 5

2.11

✔

✔

✔

✔

CC-CKR-2/CCR2A

Chemokine receptor 2

2.95

 

✔

✔

✔

CBP/RSTS

CREB binding protein

3.00

 

✔

  

CC-CKR-3/CD193

Chemokine receptor 3

4.64

 

✔

 

✔

Th1\Th2 immune response

      

BSF2/HGF

Interleukin 6

2.16

✔

✔

✔

✔

CTLA4

Cytotoxic T-lymphocyte-associated protein 4

2.64

 

✔

  

IRF4

Interferon regulatory factor 4

9.27

✔

✔

  

CD154/CD40L

CD40 ligand

-2.13

✓

✓

✓

✓

4-1BB/CD137

Tumor necrosis factor receptor superfamily

-3.49

✔

✔

 

✔

Transcriptional Factors

      

SOCS2

Suppressor of cytokine signaling 2

2.09

 

✔

✔