From: Molecular profiling of T-helper immune genes during dengue virus infection
Gene | Gene name | Fold Change | Immune cell activation | Inflammatory responses | Thrombo-cytopenia | Vascular permeability |
---|---|---|---|---|---|---|
Th1 immune response | ||||||
CSF2 | GMCSF | 2.08 | ✔ | ✔ | ✔ | ✔ |
APT1LG1/CD178 | FASLG | 2.18 | ✔ | |||
INHA | Inhibin, alpha | 2.19 | ✓ | |||
CLMF/CLMF2 | Interleukin 12B | 2.20 | ✔ | ✔ | ||
CD80 | CD28LG/CD28LG1 | 2.29 | ✓ | |||
IFNG | Interferon, gamma | 2.85 | ✔ | ✔ | ✔ | |
IL18 | Interleukin 18 | 3.69 | ✔ | ✔ | ✔ | |
IL2 | Interleukin 2 | 3.97 | ✔ | ✔ | ✔ | ✔ |
TLR6 | Toll-like receptor 6 | 8.68 | ✔ | ✔ | ✔ | ✔ |
CD182/CD183 | CXCR3 | -2.12 | ✓ | ✓ | ||
Th2 immune response | ||||||
RANTES | Chemokine ligand 5 | 2.11 | ✔ | ✔ | ✔ | ✔ |
CC-CKR-2/CCR2A | Chemokine receptor 2 | 2.95 | ✔ | ✔ | ✔ | |
CBP/RSTS | CREB binding protein | 3.00 | ✔ | |||
CC-CKR-3/CD193 | Chemokine receptor 3 | 4.64 | ✔ | ✔ | ||
Th1\Th2 immune response | ||||||
BSF2/HGF | Interleukin 6 | 2.16 | ✔ | ✔ | ✔ | ✔ |
CTLA4 | Cytotoxic T-lymphocyte-associated protein 4 | 2.64 | ✔ | |||
IRF4 | Interferon regulatory factor 4 | 9.27 | ✔ | ✔ | ||
CD154/CD40L | CD40 ligand | -2.13 | ✓ | ✓ | ✓ | ✓ |
4-1BB/CD137 | Tumor necrosis factor receptor superfamily | -3.49 | ✔ | ✔ | ✔ | |
Transcriptional Factors | ||||||
SOCS2 | Suppressor of cytokine signaling 2 | 2.09 | ✔ | ✔ |