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Figure 2 | Virology Journal

Figure 2

From: Central nervous system Toll-like receptor expression in response to Theiler's murine encephalomyelitis virus-induced demyelination disease in resistant and susceptible mouse strains

Figure 2

Viral protein expression in microglia, astrocytes, oligodendrocytes and neurons in the spinal cord of TMEV-infected mice. A. Left panes shows microgliosis and astrogliosis (immunocytochemistry, brown cells, red surrounded areas) at sites where viral protein VP1 expression (in situ hybridization, silver grains) was present, while right panes shows Iba+ microglia and GFAP+ astrocytes co-localized with VP1 hybridization (orange arrow, higher magnification in inset) B. VP1 expression was also found to co-localize with CAII+ oligodendrocytes (top, green arrows) and NeuN+ neurons (bottom, green arrow). Expression of VP1 was not found to occur in TCRαβ-positive T-cells (not shown). In all instances VP1 expression could be found outside of the cell type assayed. Scale bars: green = 5 μm, red = 25 μm.

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Virology Journal

ISSN: 1743-422X