Figure 6From: Effects of vaccinia virus uracil DNA glycosylase catalytic site and deoxyuridine triphosphatase deletion mutations individually and together on replication in active and quiescent cells and pathogenesis in miceWeight loss and lethality following intranasal infections. Six-week female BALB/c mice were infected intranasally with 104-106 PFU of purified WR or mutant or revertant (Rev) viruses. Mice were weighed daily and animals that lost ≥ 30% of their original weight were terminated. The % average weight of each group at the indicated times was plotted (A-F). Graphs represent mean of experiment (n = 5 mice/group) and bars represent the standard error of the mean. (G-L) The % of surviving mice at each time was plotted.Back to article page