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Table 2 Aetiology and outcome for each of the selected AES studies*

From: The incidence of acute encephalitis syndrome in Western industrialised and tropical countries

Study (Publication Year) Study Year Ages Aetiology confirmed Fatality Rate% Sequelae %
Klemola et al. (1965)[5], Kaeaeriaeinen et al. (1964)[6] 1945–1963 All ages 40% from 1958 onwards 10 33
Beghi et al. (1984)[4] 1950–1981 All ages 15.3 3.8 not reported
Henrich et al. (2003).[35] 1993–1998 All ages not reported not reported not reported
Pedersen (1956)[37] 1952–54 All ages not reported not reported not reported
Nicolosi(1986)[36] 1950–1981 All ages 15 3.8 not reported
Ponka et al. (1982)[13] 1980 All ages not reported not reported not reported
Khetsuriani et al. (2002)[18] 1988–1997 All ages 40.5 7.4 not reported
Khetsuriani et al. (2007)[34] 1988–1997 All ages 81.5 100 not applicable
Kamei et al. (2000)[17] 1989–1991 All ages 48.8 not reported not reported
Davison et al. (2003)[20] 1989–1998 All ages 40.1 9.7 56 (mild deficits)
Trevejo (2004)[19] 1990–1999 All ages 43.7 not reported not reported
Mailles, et al. (2007)[21] 2000–2002 All ages 16.8 15–28 not reported
Rantalaiho et al. (2001)[7] 1967–1991 >= 15 yrs 50.6 5.6 not reported
Radhakrishnan et al. (1987)[38] 1983–1984 >15 yrs 0 20 not reported
Nwosu et al.(2001)[33] 1991–1993 >= 16 yrs 0 50 0
Kupila et al. (2006)[9] 1999–2003 >= 16 yrs 35.7 not reported 71 (mild-severe deficits)
Koskiniemi et al. (1991) [8] 1968–1987 1 mths-16 yrs 68 3 7 severely damaged
Rantakallio et al. (1986)[39] 1966–1972 <14 yrs 38.1 not reported not reported
Koskiniemi et al. (1997)[11] 1983–1984 1 mths-15 yrs 62.9 not reported not reported
Ilias et al. (2006)[14] 2000–2004 <14 yrs 72.2 0 not reported
Wang et al. (1981)[40] 1972–1980 <=16 yrs 36 of all viral CNS infections not reported not reported
Rantala & Uhari (1989)[12] 1973–1987 <16 yrs 61.1 1.1 not reported
Wong et al. (1987)[41] 1975–1986 <14 yrs 26 28 24
Cizman et al. (1993)[15] 1979–1991 1mths-15 yrs 68.2 1.8 24 (neurological deficits)
Ishikawaet al. (1993)[16] 1984–1990 <15 yrs 41 7.8 66 (neurological deficits)
  1. *Studies covering all ages are listed first, followed by adult studies and then paediatric studies. Within each section the studies are ordered by type; longitudinal (L), then prospective (P) and then retrospective (R) studies. Yrs Years, Mths Months.