Elicitation of protective immune responses using a bivalent H5N1 VLP vaccine

Table 1 Virological and pathological assessment following Indo/05 challenge

Vaccine ^a	% Body Weight ^b	% Body Weight ^c	Plaque Titer ^d	Activity ^e	Dyspnea ^f
Clade 2 VLP	102%	103%	<1.00e+2	0	0
Clade 1/Clade 2 VLP	102%	101%	5.25e+3	0	0
Clade 1 VLP	95%	76%	5.73e+6	2	1
Clade 1/Clade 2 rHA	98%	89%	3.54e+5	1	0
Mock	94%	77%	5.94e+6	2	1

^aVaccine administered at weeks 0 and 3.
^bPercentage of original weight at day 3 post-challenge.
^cPercentage of original weight at day 6 post-challenge.
^dParticle forming units (pfu) per milliliter (ml) in the lungs of mice at day 3 post-challenge.
< 1.00e + 2 = Viral titers less than 100 pfu/ml.
^eActivity score. 0 = Full activity, 1 = slow to respond to touch, but still mobile, 2 = little response to touch.
^fDyspnea. 0 = no shortness of breadth. 1 = heavy breathing and shortness of breadth.

ISSN: 1743-422X