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Table 1 Virological and pathological assessment following Indo/05 challenge

From: Elicitation of protective immune responses using a bivalent H5N1 VLP vaccine

Vaccine a % Body Weight b % Body Weight c Plaque Titer d Activity e Dyspnea f
Clade 2 VLP 102% 103% <1.00e+2 0 0
Clade 1/Clade 2 VLP 102% 101% 5.25e+3 0 0
Clade 1 VLP 95% 76% 5.73e+6 2 1
Clade 1/Clade 2 rHA 98% 89% 3.54e+5 1 0
Mock 94% 77% 5.94e+6 2 1
  1. aVaccine administered at weeks 0 and 3.
  2. bPercentage of original weight at day 3 post-challenge.
  3. cPercentage of original weight at day 6 post-challenge.
  4. dParticle forming units (pfu) per milliliter (ml) in the lungs of mice at day 3 post-challenge.
  5. < 1.00e + 2 = Viral titers less than 100 pfu/ml.
  6. eActivity score. 0 = Full activity, 1 = slow to respond to touch, but still mobile, 2 = little response to touch.
  7. fDyspnea. 0 = no shortness of breadth. 1 = heavy breathing and shortness of breadth.