Hemaggutination-inhibition (HAI) titers. Week 5 serum HAI antibody responses were assessed against H5N1 clade 1 (VN/04) and clade 2 (Indo/05, WS/05, Anh/05) viruses. Bars indicate geometric mean titer (GMT) +/- 95% CI. A) Clade 2 VLP; B) Clade 1/Clade 2 VLPs; C) Clade 1 VLP; D) Clade 1/Clade 2 rHA; E) Mock. * indicates p < 0.05 compared to Clade 1 VLPs.