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Figure 5 | Virology Journal

Figure 5

From: Molecular and macromolecular alterations of recombinant adenoviral vectors do not resolve changes in hepatic drug metabolism during infection

Figure 5

A Single Dose of Active and Inactive Adenovirus Significantly Affects Hepatic CYP2C11 Catalytic Activity for Four Days. In vitro catalytic activity of CYP2C11 microsomal proteins, as determined by measuring the production of the isoform-specific testosterone metabolite, 2α-hydroxytestosterone. Male Sprague-Dawley rats were given either: phosphate buffered saline (Vehicle), wild type virus (WT), first generation recombinant virus expressing beta-galactosidase (AdlacZ), PEGylated AdlacZ, (PEGAd), helper-dependent virus (HDAd), or inactivated virus (UVAd). Values are presented as the mean ± standard error of 4 animals/treatment/time point. Statistical significance was determined between each treatment group and vehicle controls by one-way analysis of variance with a Bonferroni/Dunn post-hoc test. *p ≤ 0.05, **p ≤ 0.01.

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Virology Journal

ISSN: 1743-422X