Figure 4

A Single Dose of Adenovirus Significantly Suppresses Hepatic CYP2C11 1 and 4 Days After Administration. Mean hepatic CYP2C11 protein expression levels 0.25 (A), 1 (B), 4 (C), and 14 (D) days after a single dose of: phosphate buffered saline (Vehicle), wild type adenovirus 5 (WT), first generation recombinant adenovirus expressing beta-galactosidase (AdlacZ), PEGylated AdlacZ, (PEGAd), helper-dependent adenovirus (HDAd), or inactivated virus (UVAd). Protein levels are reported as the relative density of positive bands with respect to that of a known protein standard in arbitrary units. Values are presented as the mean ± standard error of 4 animals/treatment/timepoint. Statistical significance was determined between individual treatment groups and vehicle controls by one-way analysis of variance with a Bonferroni/Dunn post-hoc analysis, *P ≤ 0.05 and **P ≤ 0.01.