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Table 3 Clinical and laboratory history of genital HPV infection during pregnancy and delivery and distribution of HPV types in maternal, newborn and placental samples.

From: Transplacental transmission of Human Papillomavirus

  Epidemiology maternal HPV type in samples
  Pregnancy Delivery Maternal Placental Newborn
Case HPV lesion type HPV lesion site Type HPV lesion Genital Peripheral blood Fetal side Maternal side Aspirates nasopharyngeal Buccal and body Cord blood
        Biopsy Brush Biopsy Brush    
        Border Central   Border Central     
1 Warts VV V No 6/11           
2 HGSIL C C No 16+6/11     6/11 6/11   6/11   6/11  
3 HGSIL C C Yes 16+31       16     
4 Warts VV V No 16+42+54      16   42+16   42  
5 LGSIL C C Yes 18           
6 Warts VV C No 6/11+16+31           
7 Warts C+VV+VG V No 6/11+42   6/11    6/11    6/11 6/11  
8 HGSIL C C Yes 52   6/11      6/11+52 6/11   
9 LGSIL C V Yes 42+51+NC*           
10 Warts VV+VG V No 6/11           
11 LGSIL C V No 18     18    18 18   18
12 Warts VV V+F No NC*           
13 LGSIL C C Yes 6/11+42           
14 LGSIL C C Yes 16+42+58     6/11     59   
15 Warts C+VV+VG V Yes 6/11+42           
16 Warts VV+VG C No 6/11           
17 HGSIL C C Yes 18+51           
18 Warts VV+P C No 42+59           
19 Warts VV V No 6/11 6/11          
20 HGSIL C C No 42+35           
21 Warts VV C Yes 52           52
22 Warts VV C Yes 34           
23 Warts VV+VG V Yes 18           
24 Warts VV V No 16+73 16          
25 Warts VV+VG C No 68           
26 Warts C V Yes 6/11+16    16        
27 Warts C+VV+VG V No 16+58           
28 Warts VV C Yes 6/11+33           
29 LGSIL C V No 16           
30 LGSIL C V Yes 52+42+58+54     58       
31 LGSIL C C No 16           
32 Warts VV C No 6/11           
33 HGSIL C V Yes 18   18         
34 Warts VV V Yes 11         11   
35 Warts VV+VG C Yes 42          42  
36 LGSIL C V Yes 16           
37 HGSIL C C Yes 58          6/11+52  
38 HGSIL C V No 6/11+18           
39 HGSIL C C Yes 18+31           
40 Warts VV V No 6/11     6/11       
41 Warts VV C No 42+35+NC*           
42 LGSIL C C Yes 42           
43 LGSIL C C yes 16+18+42           
44 LGSIL C+VV+VG C Yes 18+26           
45 Warts VV V Yes 6/11+58+59   6/11   6/11 6/11     6/11 6/11
46 Warts VV+VG C Yes 6           
47 Warts VV V Yes 35           
48 Warts VV V No 70           
49 Warts VV+VG V No 6+45 58          
  1. The HPV types were identified by both multiplex PCR and nested multiplex PCR methods. *NC = HPV DNA positive but could not be classified by type.
  2. Type of delivery = C – cesarean section; V- vaginal; and V+ F – vaginal with forceps.
  3. HPV lesion site = C – cervical; VG – vaginal; VV – vulva; P – perineal.
  4. HPV lesion type = Warts – genital warts; LGSIL – low-grade squamous intraepithelial lesions; HGSIL – high-grade squamous intraepithelial lesions.