Table 2 Microarray analysis revealed characteristic changes in gene expression profiling of HeLa cells during HCV protein expression from VT7-HCV_7.9 (6 h p.i)

Apoptosis

RAD21 homolog (S. pombe)

NM_006265

RAD21

2,93

Protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform

NM_002715

PPP2CA

2,07

Hepatocellular carcinoma-associated antigen 66

NM_018428

HCA66

1,7

Glucose regulated protein, 58 kD

NM_005313

PDIA3

1,67

Insulin-like growth factor 1 receptor

NM_000875

IGF1R

-1,64

Sphingosine kinase type 2 isoform

BC006161

SPHK2

-1,87

Mitochondrial functions

ATP synthase, H+ transporting, mitochondrial F1 complex

NM_005174

ATP5C1

2,6

ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit

NM_001697

ATP5O

2,48

Complement component 1, q subcomponent binding protein

NM_001212

C1QBP

2,27

NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 9 (22 kD, B22)

NM_005005

NDUFB9

2,21

Voltage-dependent anion channel 1

NM_003374

VDAC1

1,86

Surfeit 1

NM_003172

SURF1

1,69

Solute carrier family 25, member 10

NM_012140

SLC25A10

-2,41

Lipid metabolism/Oxidative stress

DnaJ (Hsp40) homolog, subfamily C, member 10

AK027647

DNAJC10

3,68

Glutathione peroxidase 4 (phospholipid hydroperoxidase)

NM_002085

GPX4

2,05

Fatty acid binding protein 5 (psoriasis-associated)

NM_001444

FABP5

1,81

Nuclear receptor subfamily 5, group A, member 2

NM_003822

NR5A2

1,81

Peroxiredoxin 1

NM_002574

PRDX1

1,71

StAR-related lipid transfer (START) domain containing 4

AK054566

STARD4

1,63

Cytochrome P450, family 19, subfamily A, polypeptide 1

NM_031226

CYP19A1

1,57

Glutathione S-transferase M1

NM_000561

GSTM1

-1,65

ATPase, class I, type 8B, member 4

NM_024837

ATP8B4

-1,58

24-dehydrocholesterol reductase

NM_014762

DHCR24

-1,81

Peripheral myelin protein 2

NM_002677

PMP2

-1,84

Glucose-6-phosphate dehydrogenase

NM_000402

G6PD

-2,38

Membrane transport

Clathrin, light polypeptide (Lca)

NM_007096

CLTA

3,05

Centaurin, gamma 2

NM_014914

CENTG2

2,1

Adaptor-related protein complex 3, sigma 1 subunit

NM_001284

AP3S1

1,76

Coatomer protein complex, subunit beta

NM_016451

COPB1

1,73

USO1 homolog, vesicle docking protein (yeast)

NM_003715

USO1

1,73

SEC24 related gene family, member B (S. cerevisiae)

NM_006323

SEC24B

1,72

Paralemmin

NM_002579

PALM

1,67

Adaptor-related protein complex 2, mu 1 subunit

NM_004068

AP2M1

-1,85

Lectin, mannose-binding 2-like

NM_030805

LMAN2L

-1,89

Reticulon 4

AF148537

RTN4

1,64

DNAbinding/Cell cycle

Histone cluster 1, H2am

NM_003514

HIST1H2AM

7,03

Histone cluster 1, H4h

NM_003543

HIST1H4H

6,09

Histone cluster 2, H4a

NM_003548

HIST2H4A

3,67

H2A histone family, member Z

NM_002106

H2AFZ

3,58

Histone cluster 1, H4d

NM_003539

HIST1H4D

2,68

H3 histone, family 3B (H3.3B)

AF218029

H3F3B

2,65

CDC28 protein kinase regulatory subunit 2

NM_001827

CKS2

2,21

Karyopherin alpha 2 (RAG cohort 1, importin alpha 1)

NM_002266

KPNA2

1,78

Nuclear receptor subfamily 5, group A, member 2

NM_003822

NR5A2

1,81

Inflammatory response/Signalling

Interleukin 6 (interferon, beta 2)

NM_000600

IL6

5,67

Chloride intracellular channel 1

NM_001288

CLIC1

2,81

Neuroepithelial cell transforming gene 1

BC010285

NET1

2,28

Interleukin-1 receptor-associated kinase 1

NM_001569

IRAK1

2,23

CDC42 small effector 1

NM_020239

CDC42SE1

1,73

Others

DEAD (Asp-Glu-Ala-Asp) box polypeptide 5

NM_004396

DDX5

2,91

TP53RK binding protein

NM_016058

TPRKB

2,51

T-complex 1

NM_030752

TCP1

2,43

Eukaryotic translation initiation factor 4E

NM_001968

EIF4E

2,23

Olfactomedin 1

NM_014279

OLFM1

2,03

Leucine zipper, down-regulated in cancer 1

NM_012317

LDOC1

-1,66

HtrA serine peptidase 3

AY040094

HTRA3

-1,84