Changes of HBpreSAg levels and other serologic markers of the three Types patients for follow up study. Black square represents HBpreSAg (OD450), black triangle represents HBsAg (OD450), white circle represents ALT (IU/l) and white triangle represents HBV DNA copies (copies/ml). A typical sample for Type I-III was shown. (A) The levels of HBpreSAg, HBsAg, ALT and HBV DNA decreased significantly without rebound in Type I patients. (B) Type II patients responded to the IFN-α treatment well initially but rebounded at the end check point. (C) Type III patients did not respond well to the IFN-α treatment.