TY - JOUR AU - Alter, H. J. AU - Seeff, L. B. PY - 2000 DA - 2000// TI - Recovery, persistence and sequelae in hepatitis C virus infection: a perspective on long-term outcome JO - Seminar Liver Disease VL - 20 UR - https://doi.org/10.1055/s-2000-9505 DO - 10.1055/s-2000-9505 ID - Alter2000 ER - TY - JOUR AU - Lauer, G. AU - Walker, B. PY - 2001 DA - 2001// TI - Medical progress: hepatitis C virus infection JO - New Eng J Med VL - 345 UR - https://doi.org/10.1056/NEJM200107053450107 DO - 10.1056/NEJM200107053450107 ID - Lauer2001 ER - TY - JOUR AU - Alter, M. J. PY - 1997 DA - 1997// TI - Epidemiology of hepatitis C JO - Hepatology VL - 26 UR - https://doi.org/10.1002/hep.510260711 DO - 10.1002/hep.510260711 ID - Alter1997 ER - TY - JOUR AU - Liang, T. J. AU - Rehermann, B. AU - Seeff, L. B. AU - Hoofnagle, J. H. PY - 2000 DA - 2000// TI - Pathogenesis, natural history, treatment, and prevention of hepatitis C JO - Ann Intern Med VL - 132 UR - https://doi.org/10.7326/0003-4819-132-4-200002150-00008 DO - 10.7326/0003-4819-132-4-200002150-00008 ID - Liang2000 ER - TY - JOUR AU - Hoofnagle, J. H. PY - 2004 DA - 2004// TI - Hepatocellular carcinoma: Summary and recommendation JO - Gastroenterology VL - 127 UR - https://doi.org/10.1053/j.gastro.2004.09.047 DO - 10.1053/j.gastro.2004.09.047 ID - Hoofnagle2004 ER - TY - JOUR AU - El-Serag, H. B. PY - 2004 DA - 2004// TI - Hepatocellular carcinoma: recent trends in the United States JO - Gastroenterology VL - 127 UR - https://doi.org/10.1053/j.gastro.2004.09.013 DO - 10.1053/j.gastro.2004.09.013 ID - El-Serag2004 ER - TY - JOUR AU - Davis, G. L. PY - 2000 DA - 2000// TI - Current therapy for chronic hepatitis C JO - Gastroenterology VL - 118 UR - https://doi.org/10.1016/S0016-5085(00)70009-6 DO - 10.1016/S0016-5085(00)70009-6 ID - Davis2000 ER - TY - JOUR AU - Brown, R. S. PY - 2005 DA - 2005// TI - Hepatitis C and liver transplantation JO - Nature VL - 436 UR - https://doi.org/10.1038/nature04083 DO - 10.1038/nature04083 ID - Brown2005 ER - TY - JOUR AU - Davis, G. L. AU - Esteban-Mur, R. AU - Rustgi, V. AU - Hoefs, J. AU - Gordon, S. C. AU - Trepo, C. AU - Shiffman, M. L. AU - Zeuzem, S. AU - Craxi, A. AU - Ling, M. H. AU - Albrecht, J. PY - 1998 DA - 1998// TI - Interferon alfa-2b alone or in combination with ribavirin for the treatment of relapse of chronic hepatitis C. International Hepatitis Interventional Therapy Group JO - N Engl J Med VL - 339 UR - https://doi.org/10.1056/NEJM199811193392102 DO - 10.1056/NEJM199811193392102 ID - Davis1998 ER - TY - JOUR AU - Manns, M. P. AU - McHutchison, J. G. AU - Gordon, S. C. AU - Rustgi, V. K. AU - Shiffman, M. AU - Reindollar, R. AU - Goodman, Z. D. AU - Koury, K. AU - Ling, M. AU - Albrecht, J. K. PY - 2001 DA - 2001// TI - Peginterferon alpfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C: a randomized trial JO - Lancet VL - 58 UR - https://doi.org/10.1016/S0140-6736(01)06102-5 DO - 10.1016/S0140-6736(01)06102-5 ID - Manns2001 ER - TY - JOUR AU - Feld, J. J. AU - Hoofnagle, J. H. PY - 2005 DA - 2005// TI - Mechanism of action of interferon and ribavirin treatment of hepatitis C JO - Nature VL - 436 UR - https://doi.org/10.1038/nature04082 DO - 10.1038/nature04082 ID - Feld2005 ER - TY - JOUR AU - Strader, D. B. AU - Wright, T. AU - Thomas, D. L. AU - Seeff, L. B. PY - 2004 DA - 2004// TI - Diagnosis, management, and treatment of hepatitis C JO - Hepatology VL - 39 UR - https://doi.org/10.1002/hep.20119 DO - 10.1002/hep.20119 ID - Strader2004 ER - TY - JOUR AU - Fried, M. W. AU - Shiffman, M. L. AU - Reddy, K. R. AU - Smith, C. AU - Marinos, G. AU - Goncales, F. L. AU - Haussinger, D. AU - Diago, M. AU - Carosi, G. AU - Dhumeaux, D. AU - Craxi, A. AU - Lin, A. AU - Hoffman, J. AU - Yu, J. PY - 2002 DA - 2002// TI - Peginterferon alfa-2a plus ribavirin for chronic hepatitis C virus infection JO - New Eng J Med VL - 347 UR - https://doi.org/10.1056/NEJMoa020047 DO - 10.1056/NEJMoa020047 ID - Fried2002 ER - TY - JOUR AU - Simmonds, P. PY - 2004 DA - 2004// TI - Genetic diversity and evolution of hepatitis C virus–15 years on JO - J Gen Virol VL - 85 UR - https://doi.org/10.1099/vir.0.80401-0 DO - 10.1099/vir.0.80401-0 ID - Simmonds2004 ER - TY - JOUR AU - Bukh, J. AU - Miller, R. H. AU - Purcell, R. H. PY - 1995 DA - 1995// TI - Genetic heterogeneity of hepatitis C virus: quasispecies and genotypes JO - Semin Liver Dis VL - 15 UR - https://doi.org/10.1055/s-2007-1007262 DO - 10.1055/s-2007-1007262 ID - Bukh1995 ER - TY - JOUR AU - Reed, K. E. AU - Rice, C. M. PY - 2000 DA - 2000// TI - Overview of hepatitis C virus genome structure, polyprotein processing and protein properties JO - Curr Top Microbiol Immunol VL - 242 ID - Reed2000 ER - TY - JOUR AU - Pawlotsky, J. M. PY - 2003 DA - 2003// TI - The nature of interferon-alpha resistance in hepatitis C virus infection JO - Current Opinion on Infectious Disease VL - 16 UR - https://doi.org/10.1097/00001432-200312000-00012 DO - 10.1097/00001432-200312000-00012 ID - Pawlotsky2003 ER - TY - JOUR AU - Pawlotsky, J. M. PY - 2003 DA - 2003// TI - Mechanisms of antiviral treatment efficacy and failure in chronic hepatitis C JO - Antiviral Research VL - 59 UR - https://doi.org/10.1016/S0166-3542(03)00088-3 DO - 10.1016/S0166-3542(03)00088-3 ID - Pawlotsky2003 ER - TY - JOUR AU - Enomoto, N. AU - Sakuma, I. AU - Asahina, Y. AU - Kurosaki, M. AU - Murakami, T. AU - Yamamoto, C. AU - Izumi, N. AU - Marumo, F. AU - Sato, C. PY - 1995 DA - 1995// TI - Comparison of full-length sequences of interferon-sensitive and resistant hepatitis C virus 1b JO - Journal of Clinical Investigation VL - 96 UR - https://doi.org/10.1172/JCI118025 DO - 10.1172/JCI118025 ID - Enomoto1995 ER - TY - JOUR AU - Enomoto, N. AU - Sakuma, I. AU - Asahina, Y. AU - Kurosaki, M. AU - Murakami, T. AU - Yamamoto, C. AU - Ogura, Y. AU - Izumi, N. AU - Marumo, F. AU - Sato, C. PY - 1996 DA - 1996// TI - Mutation in the nonstructural protein 5A gene and response to interferon in patients with chronic hepatitis C virus 1b infection JO - New Eng J Med VL - 334 UR - https://doi.org/10.1056/NEJM199601113340203 DO - 10.1056/NEJM199601113340203 ID - Enomoto1996 ER - TY - JOUR AU - Paterson, M. AU - Laxton, C. D. AU - Thomas, H. C. AU - Ackrill, A. M. AU - Foster, G. R. PY - 1999 DA - 1999// TI - Hepatitis C virus NS5A protein inhibits interferon antiviral activity but the effects do not correlate with clinical response JO - Gastroenterology VL - 117 UR - https://doi.org/10.1016/S0016-5085(99)70405-1 DO - 10.1016/S0016-5085(99)70405-1 ID - Paterson1999 ER - TY - JOUR AU - Hoffmann, W. P. AU - Zeuzem, S. AU - Sarrazin, C. PY - 2005 DA - 2005// TI - Hepatitis C virus-related resistance mechanisms to interferon alpha-based antiviral therapy JO - Journal of Clinical Virology VL - 32 UR - https://doi.org/10.1016/j.jcv.2004.08.004 DO - 10.1016/j.jcv.2004.08.004 ID - Hoffmann2005 ER - TY - JOUR AU - Schinkel, J. AU - Spoon, W. J. AU - Kroes, A. C. PY - 2004 DA - 2004// TI - Meta-analysis of mutations in the NS5A gene and hepatitis C virus resistance to interferon therapy: uniting discordant conclusions JO - Antiviral Therapy VL - 9 ID - Schinkel2004 ER - TY - JOUR AU - Nousbaum, J. AU - Polyak, S. J. AU - Ray, S. C. AU - Sullivan, D. G. AU - Larson, A. M. AU - Carithers, R. L. AU - Gretch, D. R. PY - 2000 DA - 2000// TI - Prospective characterization of full-length hepatitis C virus NS5A quasispecies during induction and combination antiviral therapy JO - Journal of Virology VL - 74 UR - https://doi.org/10.1128/JVI.74.19.9028-9038.2000 DO - 10.1128/JVI.74.19.9028-9038.2000 ID - Nousbaum2000 ER - TY - JOUR AU - Gale, M. J. AU - Korth, M. J. AU - Tang, N. M. AU - Tan, S. L. AU - Hopkins, D. A. AU - Dever, T. E. AU - Polyak, S. J. AU - Gretch, D. R. AU - Katze, M. G. PY - 2000 DA - 2000// TI - Evidence that hepatitis C virus resistance to interferon is mediated through repression of the PKR protein kinase by the nonstructural 5A protein JO - Virology VL - 230 UR - https://doi.org/10.1006/viro.1997.8493 DO - 10.1006/viro.1997.8493 ID - Gale2000 ER - TY - JOUR AU - Gale, M. AU - Blakely, C. M. AU - Kwieciszewski, B. AU - Tan, S. L. AU - Dossett, M. AU - Tang, N. M. AU - Korth, M. J. AU - Polyak, S. J. AU - Gretch, D. R. AU - Katze, M. G. PY - 1997 DA - 1997// TI - Control of PKR protein kinase by hepatitis C virus non-structural 5A protein: Molecular mechanisms of kinase regulation JO - Molecular and Cellular Biology VL - 18 UR - https://doi.org/10.1128/MCB.18.9.5208 DO - 10.1128/MCB.18.9.5208 ID - Gale1997 ER - TY - JOUR AU - Taylor, D. R. AU - Shi, S. T. AU - Romano, P. R. AU - Barber, G. N. AU - Lai, M. M. PY - 1999 DA - 1999// TI - Inhibition of the interferon-inducible protein kinase R by HCV E2 protein JO - Science VL - 285 UR - https://doi.org/10.1126/science.285.5424.107 DO - 10.1126/science.285.5424.107 ID - Taylor1999 ER - TY - JOUR AU - Blindenbacher, A. AU - Duong, F. H. AU - Hunziker, L. AU - Stutvoet, S. T. AU - Wang, X. AU - Terracciano, L. AU - Moradpour, D. AU - Blum, H. E. AU - Alonzi, T. AU - Tripodi, M. AU - La Monica, N. AU - Heim, M. H. PY - 2003 DA - 2003// TI - Expression of hepatitis C virus proteins inhibits interferon alpha signaling in the liver of transgenic mice JO - Gastroenterology VL - 124 UR - https://doi.org/10.1016/S0016-5085(03)00290-7 DO - 10.1016/S0016-5085(03)00290-7 ID - Blindenbacher2003 ER - TY - JOUR AU - François, C. AU - Duverlie, G. AU - Rebouillat, D. AU - Khorsi, H. AU - Castelain, S. AU - Blum, H. E. AU - Gatignol, A. AU - Wychowski, C. AU - Moradpour, D. AU - Meurs, E. F. PY - 2003 DA - 2003// TI - Expression of hepatitis C virus proteins interferes with the antiviral action of interferon independently of PKR-mediated control of protein synthesis JO - Journal of Virology VL - 74 UR - https://doi.org/10.1128/JVI.74.12.5587-5596.2000 DO - 10.1128/JVI.74.12.5587-5596.2000 ID - François2003 ER - TY - JOUR AU - Keskinen, P. AU - Melen, K. AU - Julkunen, I. PY - 2003 DA - 2003// TI - Expression of HCV structural proteins impairs IFN-mediated antiviral response JO - Virology VL - 299 UR - https://doi.org/10.1006/viro.2002.1527 DO - 10.1006/viro.2002.1527 ID - Keskinen2003 ER - TY - JOUR AU - Lin, W. AU - Choe, W. H. AU - Hiasa, Y. AU - Kamegaya, Y. AU - Blackard, J. T. AU - Schmidt, E. V. AU - Chung, R. T. PY - 2005 DA - 2005// TI - Hepatitis C virus expression suppresses interferon signaling by degrading STAT1 JO - Gastroenterology VL - 128 UR - https://doi.org/10.1053/j.gastro.2005.02.006 DO - 10.1053/j.gastro.2005.02.006 ID - Lin2005 ER - TY - JOUR AU - Gale, M. AU - Foy, E. M. PY - 2005 DA - 2005// TI - Evasion of intracellular host defence by hepatitis C virus JO - Nature VL - 436 UR - https://doi.org/10.1038/nature04078 DO - 10.1038/nature04078 ID - Gale2005 ER - TY - JOUR AU - Kawai, T. AU - Akira, S. PY - 2006 DA - 2006// TI - Innate Immune recognition of viral infection JO - Nature Immunol VL - 7 UR - https://doi.org/10.1038/ni1303 DO - 10.1038/ni1303 ID - Kawai2006 ER - TY - JOUR AU - Uze, G. AU - Lutfalla, G. AU - Gresser, I. PY - 1990 DA - 1990// TI - Genetic transfer of a functional human interferon alpha-receptor into mouse cells: cloning and expression of its cDNA JO - Cell VL - 60 UR - https://doi.org/10.1016/0092-8674(90)90738-Z DO - 10.1016/0092-8674(90)90738-Z ID - Uze1990 ER - TY - JOUR AU - Darnell, J. E. PY - 1998 DA - 1998// TI - Studies of interferon-induced transcriptional activation uncover the Jak-STAT pathway JO - J of Interf and Cytok Res VL - 18 UR - https://doi.org/10.1089/jir.1998.18.549 DO - 10.1089/jir.1998.18.549 ID - Darnell1998 ER - TY - JOUR AU - Goodbourn, S. AU - Didcock, L. AU - Randall, R. E. PY - 2000 DA - 2000// TI - Interferons: cell signaling, immune modulation, antiviral responses and virus countermeasures JO - J of Gen Virol VL - 81 UR - https://doi.org/10.1099/0022-1317-81-10-2341 DO - 10.1099/0022-1317-81-10-2341 ID - Goodbourn2000 ER - TY - JOUR AU - Pai, M. AU - Prabhu, R. AU - Panebra, A. AU - Nangle, S. AU - Haque, S. AU - Bastian, F. AU - Garry, R. AU - Agrawal, K. AU - Goodbourn, S. AU - Dash, S. PY - 2005 DA - 2005// TI - Activation of interferon stimulated response element (ISRE) in Huh-7 cells replicating HCV subgenomic RNA JO - Intervirology VL - 48 UR - https://doi.org/10.1159/000085099 DO - 10.1159/000085099 ID - Pai2005 ER - TY - JOUR AU - Dash, S. AU - Prabhu, R. AU - Hazari, S. AU - Bastian, F. AU - Garry, R. AU - Zou, W. AU - Haque, S. AU - Joshi, V. AU - Regenstein, F. G. AU - Thung, S. N. PY - 2005 DA - 2005// TI - Interferons alpha, beta, gamma each inhibits hepatitis C virus replication at the level internal ribosome entry site mediated translation JO - Liver International VL - 25 UR - https://doi.org/10.1111/j.1478-3231.2005.01082.x DO - 10.1111/j.1478-3231.2005.01082.x ID - Dash2005 ER - TY - JOUR AU - Reddy, K. R. AU - Hoofnagle, J. H. AU - Tong, M. J. PY - 1999 DA - 1999// TI - Racial differences in responses to therapy with interferon in chronic hepatitis c. Consensus Interferon Study Group JO - Hepatology VL - 30 UR - https://doi.org/10.1002/hep.510300319 DO - 10.1002/hep.510300319 ID - Reddy1999 ER - TY - JOUR AU - Gao, B. AU - Hong, F. AU - Radaeva, S. PY - 2004 DA - 2004// TI - Host factors and failure of interferon alpha treatment in hepatitis C virus JO - Hepatology VL - 39 UR - https://doi.org/10.1002/hep.20139 DO - 10.1002/hep.20139 ID - Gao2004 ER - TY - JOUR AU - Sumpter, R. AU - Wang, C. AU - Foy, E. AU - Loo, Y. M. AU - Gale, M. PY - 2004 DA - 2004// TI - Viral evolution and interferon resistance of hepatitis C virus RNA replication in a cell culture model JO - J of Virol VL - 78 UR - https://doi.org/10.1128/JVI.78.21.11591-11604.2004 DO - 10.1128/JVI.78.21.11591-11604.2004 ID - Sumpter2004 ER - TY - JOUR AU - Namba, K. AU - Naka, K. AU - Dansako, H. AU - Nozaki, A. AU - Ikeda, M. AU - Shiratori, Y. AU - Shimotohno, K. AU - Kato, N. PY - 2004 DA - 2004// TI - Establishment of hepatitis C virus replicon cell lines possessing interferon-resistant phenotype JO - Biochem and Biophys Res Comm VL - 323 UR - https://doi.org/10.1016/j.bbrc.2004.08.091 DO - 10.1016/j.bbrc.2004.08.091 ID - Namba2004 ER - TY - JOUR AU - Naka, K. AU - Takemoto, K. AU - Abe, K. AU - Dansako, H. AU - Ikeda, M. AU - Shimotohno, K. AU - Kato, N. PY - 2005 DA - 2005// TI - Interferon resistance of hepatitis C virus replicon-harbouring cells is caused by functional disruption of type1 interferon receptors JO - J of Gen Virol VL - 86 UR - https://doi.org/10.1099/vir.0.81124-0 DO - 10.1099/vir.0.81124-0 ID - Naka2005 ER - TY - JOUR AU - Zhu, H. AU - Nelson, D. AU - Crawford, J. M. AU - Liu, C. PY - 2005 DA - 2005// TI - Defective Jak-Stat activation in hepatoma cells is associated with hepatitis C viral IFN-alpha resistance JO - J of Interf and Cytok Res VL - 25 UR - https://doi.org/10.1089/jir.2005.25.528 DO - 10.1089/jir.2005.25.528 ID - Zhu2005 ER - TY - JOUR AU - Kimball, P. AU - Verbeke, S. AU - Shiffman, M. PY - 2003 DA - 2003// TI - Comparison of 125I-interferon-alpha binding to peripheral blood cells from African-Americans and Caucasians with hepatitis C JO - J Viral Hepat VL - 10 UR - https://doi.org/10.1046/j.1365-2893.2003.00444.x DO - 10.1046/j.1365-2893.2003.00444.x ID - Kimball2003 ER - TY - JOUR AU - Branca, A. AU - Faltynek, C. AU - D, A. l. e. s. s. a. n. d. r. o. AU - Baglioni, C. PY - 1982 DA - 1982// TI - Interaction of interferon with cellular receptors: internalizationand degradation of cell-bound interferon JO - J Biol Chem VL - 257 ID - Branca1982 ER -