Progressive loss of CD3 expression after HTLV-I infection results from chromatin remodeling affecting all the CD3 genes and persists despite early viral genes silencing

Table 1 TCR/CD3 expression in cells used for the DNase I hypersensitivity assay

	Surface TCR/CD3 (flow cytometry)	mRNA transcripts (real-time RT-PCR)
Cells	CD3⁺ cells	CD3γ	CD3δ
uninfected	100%	100%	100%
HTLV-I γ⁺δ⁺	98%	85%	70%
HTLV-I γ^loδ⁺	55%	13%	44%
HTLV-I γ^-δ^-	0%	0%	0%
B cell control	0%	0%	0%
HIV-1 γ^-δ⁺ control	0%	0%	70%

ISSN: 1743-422X