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Figure 4 | Virology Journal

Figure 4

From: Progressive loss of CD3 expression after HTLV-I infection results from chromatin remodeling affecting all the CD3 genes and persists despite early viral genes silencing

Figure 4

Transcription factor accessibility to the CD3 γ promoter after HTLV-I infection. A,In vitro binding to the Spγ 1 /CD3γ Inr [22] wild-type probe was examined in EMSA assay using nuclear extracts from TCR/CD3+ uninfected WE17/10 and CD3γ-δ- HTLV-I infected WE17/10 cells. B, ChIP assay using anti-Sp1, anti-Sp2, anti-Sp3, anti-TFIID, to study the in vivo binding to the sequence surrounding the Spγ 1 /CD3γ Inr motif in TCR/CD3+uninfected and in CD3γ-δ- HTLV-I infected WE17/10 cells.

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Virology Journal

ISSN: 1743-422X