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Figure 2 | Virology Journal

Figure 2

From: Progressive loss of CD3 expression after HTLV-I infection results from chromatin remodeling affecting all the CD3 genes and persists despite early viral genes silencing

Figure 2

Functional analysis by transfection of the CD3 γ promoter activity in HTLV-I infected and uninfected cells. Luciferase activity was measured in uninfected CD3γ+δ+, HTLV-I-infected CD3γ-δ+ and CD3γ-δ- WE17/10 cells after 40 h and normalized to activity from the internal Renilla control. Expression of the wild-type CD3 γpromoter constructs (pH γ3-wt) was measured in comparison to the negative control basic vector: (pGL3-BV) set to one. The pGL3 promoter vector (pGL3-PV) was used as a positive control. The results represent at least three individual experiments, each performed in triplicate.

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Virology Journal

ISSN: 1743-422X