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Table 2 Functional classification of some of the genes of interest.

From: Blood genomic profiles of exposures to Venezuelan equine encephalitis in Cynomolgus macaques (Macaca fascicularis)

Gene ID

 

Fold Change

Toll-Like Receptors

AF051151

toll-like receptor 5

1.46 ± 0.50

AF177765

toll-like receptor 4

0.67 ± 0.27

AL050262

toll-like receptor 1

0.41 ± 0.13

AL570789

toll-like receptor 3

1.47 ± 0.48

NM_003264

toll-like receptor 2

0.50 ± 0.19

Cytokines

NM_001558

interleukin 10 receptor, alpha

0.18 ± 0.09

S36219

prostaglandin-endoperoxide synthase 1

0.30 ± 0.06

AV707896

Small inducible cytokine subfamily E, member 1

0.33 ± 0.11

D87931

Rho-associated, protein kinase 2

0.40 ± 0.13

NM_003809

tumor necrosis factor (ligand) superfamily,

0.42 ± 0.25

NM_005211

colony stimulating factor 1 receptor

0.46 ± 0.18

NM_001380

dedicator of cytokinesis 1

0.47 ± 0.24

NM_004120

guanylate binding protein 2, interferon-inducible

1.91 ± 0.29

NM_002988

chemokine (C-C motif) ligand 18

2.23 ± 0.81

NM_002186

interleukin 9 receptor

3.17 ± 2.37

AB006967

suppressor of cytokine signaling 3

3.60 ± 2.87

NM_005408

chemokine (C-C motif) ligand 13

6.00 ± 3.46

Neuronal related genes

NM_005045

reelin

0.32 ± 0.12

NM_006334

olfactomedin 1

0.34 ± 0.17

AF165124

gamma-aminobutyric acid (GABA) A receptor,

0.35 ± 0.11

AU134339

Ceroid-lipofuscinosis, neuronal 3, juvenile

0.37 ± 0.22

NM_000727

calcium channel, voltage-dependent, gamma

0.43 ± 0.18

X57548

cadherin 2, type 1, N-cadherin (neuronal)

0.44 ± 0.05

NM_000742

cholinergic receptor, nicotinic, alpha 2 (neuronal)

0.44 ± 0.18

NM_005612

RE1-silencing transcription factor

0.49 ± 0.15

NM_002738

protein kinase C, beta 1

0.49 ± 0.30

BG169625

Enolase 2 (gamma, neuronal)

0.50 ± 0.20

NM_001830

chloride channel 4

0.55 ± 0.28

M34064

cadherin 2, type 1, N-cadherin (neuronal)

0.58 ± 0.38

NM_002522

neuronal pentraxin I

0.61 ± 0.44

AF166003

potassium voltage-gated channel, member 1

1.95 ± 0.68

NM_004061

cadherin 12, type 2 (N-cadherin 2)

1.98 ± 0.82

AA975079

Ankyrin 2, neuronal

2.22 ± 0.57

NM_000620

nitric oxide synthase 1 (neuronal)

2.27 ± 0.38

AI986443

Similar to neuronal pentraxin receptor isoform 2

2.60 ± 0.40

AK001991

leucine rich repeat neuronal 3

2.80 ± 1.35

AF169693

protocadherin 20

3.02 ± 1.50

NM_014211

gamma-aminobutyric acid (GABA) A receptor, pi

3.17 ± 2.99

X90846

mitogen-activated protein kinase kinase kinase 10

6.00 ± 1.85

AA243675

Solute carrier family 1

7.37 ± 2.78

AI912373

Neuronal guanine nucleotide exchange factor

29.3 ± 7.91

Caspase pathway

NM_001223

caspase 1

0.26 ± 0.16

NM_004131

granzyme B

1.68 ± 0.47

AU125557

Caspase 3

2.09 ± 0.88

H22169

Lamin A/C

3.62 ± 0.80

NM_001230

caspase 10

4.43 ± 1.33

AA041298

Caspase 4

28.3 ± 5.56

Induction of Apoptosis

AF181850

inhibitor of growth family, member 1

2.09 ± 0.40

AI591151

parathyroid hormone-like hormone

21.6 ± 7.25

L26165

cyclin-dependent kinase inhibitor 1A

2.11 ± 0.84

NM_000546

tumor protein p53

2.37 ± 1.05

NM_001230

caspase 10

4.43 ± 1.33

NM_002048

growth arrest-specific 1

4.14 ± 0.80

NM_003123

sialophorin (leukosialin, CD43)

3.01 ± 1.10

X90846

mitogen-activated protein kinase kinase kinase 10

6.00 ± 1.85

Integrins

BG032225

integrin beta 1 binding protein 1

0.63 ± 0.06

N95414

Integrin, alpha 2

0.39 ± 0.23

NM_000885

integrin, alpha 4

0.50 ± 0.21

NM_000887

integrin, alpha X

0.27 ± 0.17

AW513695

Integrin, beta 1

0.46 ± 0.18

AL581999

Integrin, beta 7

0.31 ± 0.07

AA569711

Integrin, beta 8

0.65 ± 0.15

Immune Response

M12824

CD8a molecule

0.20 ± 0.12

NM_002647

phosphoinositide-3-kinase, class 3

0.23 ± 0.11

NM_003998

nuclear factor of kappa light polypeptide

0.32 ± 0.11

NM_000569

Fc fragment of IgG, low affinity IIIa, receptor

0.34 ± 0.11

NM_001734

complement component 1, s subcomponent

0.34 ± 0.18

AF077196

regulatory factor X-associated ankyrin-containing

0.36 ± 0.14

AL050262

toll-like receptor 1

0.41 ± 0.13

X14831

carcinoembryonic antigen-related cell adhesion

0.42 ± 0.20

S82807

thyroid stimulating hormone receptor

2.17 ± 1.22

L13210

lectin, galactoside-binding protein

2.32 ± 0.42

AF004231

leukocyte immunoglobulin-like receptor

2.41 ± 1.45

M14058

complement component 1, r subcomponent

2.51 ± 2.44

NM_003123

sialophorin (leukosialin, CD43)

3.01 ± 1.10

NM_000063

complement component 2

3.26 ± 1.16

NM_003319

titin

3.68 ± 1.64

NM_003804

(TNFRSF)-interacting serine-threonine kinase 1

3.69 ± 1.82

NM_004415

desmoplakin

4.91 ± 4.10

D90277

carcinoembryonic antigen-related cell adhesion

6.81 ± 4.05