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Table 1 Subjects and laboratory studies

From: Phenotype and envelope gene diversity of nef-deleted HIV-1 isolated from long-term survivors infected from a single source

Subject

Date of infection

Date of blood sample

Virus name

CD4+ T-cell count (cells/μl)a

Viral load (RNA copies/ml)b

Antiretroviral drugsc

Status of HIV-1 progressiond

D36

01/1981

07/1995

D36E

552

1500

ABC, AZT, NVP (1/1999–9/2004)

SP

  

01/1999

D36L

160

9900

ABC, NVP, 3TC (9/2004-present)

 

C18

08/1983

01/1992

C18E

690

N/A

None

LTNP

  

03/1994

C18L

809

2805

  

C98

01/1982

07/1993

C98E

880

N/A

d4T, NVP, IND (11/1999-death)

SP

  

11/1999

C98L

585

BD

  
  1. aCD4+ T-cell levels were measured by flow cytometry.
  2. bPlasma HIV-1 RNA was measured using COBAS AMPLICOR monitor version 1.0 (Roche Molecular Diagnostic Systems, Branchburg, N.J.) prior to July 1999 and version 1.5 after July 1999. HIV-1 RNA levels of <400 copies/ml (version 1.0) or <50 copies/ml (version 1.5) were considered below detection. BD, below detection; N/A, not available.
  3. cABC, abacavir; AZT, zidovudine; NVP, nevirapine; 3TC, lamivudine; d4T, stavudine; IND, indinavir.
  4. dSP, slow progressor; LTNP, long-term nonprogressor. Comprehensive laboratory data collected since 1993 and detailed clinical history of the study subjects has been published previously [3, 4, 32], which was used to classify subjects as SP or LTNP.