Ā | Ā | Ā | Ā | Mean peak challenge virus titer (log10TCID50/ml)c | Mean sum of the daily challenge virus titers (log10TCID50/ml)d | Post-challenge serum HAI titerb | ||
---|---|---|---|---|---|---|---|---|
Virusa | No. animals | Pre-challenge serum HAI titerb | NP swab | TL | NP swab | TL | Ā | |
1 | HPIV1 wt | 12 | 6.7 Ā± 0.6 (12/12) | 0.8 Ā± 0.2 f | 0.7 Ā± 0.1 | 2.3 Ā± 0.2 | 2.4 Ā± 0.2 | 6.6 Ā± 0.5 |
2e | rHPIV1-CR84G | 4 | 3.8 Ā± 0.9 (3/4) | ā¤0.5 Ā± 0.0 | ā¤0.5 Ā± 0.0 | ā¤2.0 Ā± 0.0 | ā¤2.0 Ā± 0.0 | 4.4 Ā± 1.2 |
3e | rHPIV1-CR84GHNT553A | 12 | 6.0 Ā± 0.6 (11/12) | 0.6 Ā± 0.1 | 0.6 Ā± 0.1 | 2.1 Ā± 0.1 | 2.1 Ā± 0.1 | 7.9 Ā± 0.4 |
4e | rHPIV1-CĪ170 | 6 | 5.5 Ā± 0.4 (6/6) | ā¤0.5 Ā± 0.0 | ā¤0.5 Ā± 0.0 | ā¤2.0 Ā± 0.0 | ā¤2.0 Ā± 0.0 | 6.5 Ā± 0.4 |
5 | rHPIV1-LY942A | 4 | 6.3 Ā± 1.2 (4/4) | 1.1 Ā± 0.2 | 1.2 Ā± 0.2 | 2.7 Ā± 0.3 | 2.8 Ā± 0.3 | 8.9 Ā± 1.1 |
6e | rHPIV1-CR84GHNT553ALY942A | 8 | 2.0 Ā± 0.0 (3/8) | 0.8 Ā± 0.2 | 0.8 Ā± 0.2 | 2.6 Ā± 0.3 | 2.4 Ā± 0.3 | 3.3 Ā± 0.7 |
7 | rHPIV1-CR84GLĪ1710ā11 | 4 | 6.1 Ā± 1.8 (3/4) | 3.4 Ā± 0.6 | 3.0 Ā± 0.6 | 8.4 Ā± 2.0 | 8.3 Ā± 1.3 | 6.9 Ā± 1.5 |
8 | rHPIV1-CR84G/Ī170HNT553ALY942A | 4 | ā¤1.0 Ā± 0.0 (0/4) | 2.2 Ā± 0.2 | 1.8 Ā± 0.5 | 5.1 Ā± 0.3 | 4.3 Ā± 1.3 | 5.5 Ā± 1.6 |
9 | rHPIV1-CR84G/Ī170HNT553ALĪ1710ā11 | 4 | ā¤1.0 Ā± 0.0 (0/4) | 4.5 Ā± 0.9 | 3.4 Ā± 0.4 | 11.8 Ā± 2.5 | 8.1 Ā± 1.3 | 7.5 Ā± 1.4 |
10 | Non-immune | 7 | ā¤1.0 Ā± 0.0 (0/4) | 5.0 Ā± 0.6 | 3.9 Ā± 0.5 | 14.8 Ā± 1.2 | 11.0 Ā± 2.5 | 6.0 Ā± 1.3 |