Figure 1From: HIV-1 Vpr activates the G2 checkpoint through manipulation of the ubiquitin proteasome systemRole of the ubiquitin proteasome system in Vpr-induced G2 arrest. Incubation with epoxomicin or overexpression of Ub(K48R) block Vpr induced G2 arrest when induced by Vpr, but not when induced by the topoisomerase inhibitor, etoposide.Back to article page