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Figure 1 | Virology Journal

Figure 1

From: Repressor element-1 silencing transcription factor/neuronal restrictive silencer factor (REST/NRSF) can regulate HSV-1 immediate-early transcription via histone modification

Figure 1

HSV-1 genome and HSV-1 RE-1/NRSE sequence. A. HSV-1 genome is composed of two covalently linked components, designated as UL (Unique Long) or US (Unique Short). Each component contains unique sequences bracketed by inverted and terminal repeats (TRL and IRL). The ICP22 gene is present in US and one of the two ICP4 is located at the junction of US and IRS since the genes that are encoded within the repeat sequences are present twice in the viral genome. The HSV-1 RE-1/NRSE is mapped from 132082 to 132103 according to the HSV-1 complete genome sequence accession number X14112. B. Putative HSV-1 RE-1/NRSE. The HSV-1 RE-1/NRSE sequence was identified to overlap ICP22 TATA box (Bold) compared to consensus sequence. The core sequence is underlined. The matching result indicated that the homology is 76%. W: A or T; N: any nucleotide; S: G or C; Y: C or T; R: A or G.

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