Skip to main content

Table 1

From: Biochemical characterization of the fidelity of poliovirus RNA-dependent RNA polymerase

Sym-Sub U

  

[ATP] (μM)

Amplitude (nM)

kobs (sec-1)

50

110 (± 4.4)

24 (± 4.7)

100

160 (± 25)

30 (± 21)

200

100 (± 6.1)

47 (± 16)

K d ( μM)

k pol (sec-1)

kpol/Kd ( μM-1 sec-1)

120 (± 74)

74 (± 33)

0.62

Sym-Sub C

  

[GTP] ( μM)

Amplitude (nM)

kobs (sec-1)

1

150 (± 13)

6.7 (± 1.1)

2

120 (± 4.7)

9.7 (± 1.3)

3

120 (± 13)

9.9 (± 3.4)

K d ( μM)

k pol (sec-1)

k pol / Kd ( μM-1 sec-1)

0.93 (± 0.45)

13 (± 2.0)

9.4

Sym-Sub A

  

[UTP] ( μM)

Amplitude (nM)

kobs (sec-1)

75

270 (± 13)

62 (± 17)

150

260 (± 6.7)

71 (± 25)

500

250 (± 71)

80 (± 21)

K d ( μM)

k pol (sec-1)

k pol / Kd ( μM-1 sec-1)

27 (± 0.95)

84 (± 0.48)

3.1

Sym-Sub G

  

[CTP] ( μM)

Amplitude (nM)

kobs (sec-1)

10

89 (± 16)

10 (± 4.8)

25

100 (± 36)

19 (± 2.1)

100

110 (± 38)

38 (± 5.8)

K d ( μM)

k pol (sec-1)

k pol / Kd ( μM-1 sec-1)

44 (± 7.2)

55 (± 3.8)

1.25