From: Genome sequence analysis of La Crosse virus and in vitro and in vivo phenotypes
Virus | Neurovirulence (IC) (LD50 log10 PFU) | Neuroinvasiveness (IP) (LD50 log10 PFU) | ||
---|---|---|---|---|
Suckling micea | Weanling miceb | Suckling mice | Weanling mice | |
LACV/human/1960 | 1.35 | 1.30 | 2.17 | 2.56 |
LACV/human/1960-clonec | 1.37 | -0.25 | 1.76 | > 6.0 |
LACV/human/1978 | 0.37 | -0.50 | 0.57 | 1.75 |
LACV/human1978-clone | 0.42 | -0.15 | 0.83 | 1.25 |
LACV/mosquito/1978 | 1.19 | 1.13 | 1.08 | 1.84 |
LACV/mosquito/1978-clone | 1.36 | 1.50 | 1.29 | 2.40 |