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Table 5 La Crosse neurovirulence and neuroinvasiveness after intracerebral (IC) or intraperitoneal (IP) inoculation of Swiss Webster mice.

From: Genome sequence analysis of La Crosse virus and in vitro and in vivo phenotypes

Virus Neurovirulence (IC) (LD50 log10 PFU) Neuroinvasiveness (IP) (LD50 log10 PFU)
  Suckling micea Weanling miceb Suckling mice Weanling mice
LACV/human/1960 1.35 1.30 2.17 2.56
LACV/human/1960-clonec 1.37 -0.25 1.76 > 6.0
LACV/human/1978 0.37 -0.50 0.57 1.75
LACV/human1978-clone 0.42 -0.15 0.83 1.25
LACV/mosquito/1978 1.19 1.13 1.08 1.84
LACV/mosquito/1978-clone 1.36 1.50 1.29 2.40
  1. aSuckling mice are 2–3 days old.
  2. bWeanling mice are 21–23 days old.
  3. cBiologically cloned viruses were obtained by terminally diluting wild type parental virus three times, then amplified by an additional passage in tissue culture.