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Table 4 Host specific amino acid differences are located in the RNA polymerase (L).

From: Genome sequence analysis of La Crosse virus and in vitro and in vivo phenotypes

Amino acid position

Amino acid residue

129

V

I

484

K

R

1040

E

G

1713

T

A

1906

A

S

  1. Genetic comparisons used all wild-type parental sequences generated for this paper and published sequences of mosquito strain LACV-77 (DQ196118–DQ196120). RNA polymerase amino acid 922 was R or G in the human isolates and K in the two mosquito isolates.
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Virology Journal

ISSN: 1743-422X