Genome sequence analysis of La Crosse virus and in vitro and in vivo phenotypes

Table 3 Nucleotide differences between wild type parental and biologically cloned virus.

LACV Virus	Nucleotide substitution in indicated LACV segment^a
human/1960-clone	A525T	A503G^b	A1837G
		C2221T
human/1978-clone	No changes^c	T391C	No changes
		A1636G
		A1929G^b
mosquito/1978-clone	A719G^b	No changes	A31G
			G33A

^aParental nucleotide on left, nucleotide substitution in the cloned virus on right.
^bIndicates a nucleotide substitution resulting in an amino acid substitution.
^cParental and cloned virus have identical sequences.

ISSN: 1743-422X