Figure 7

Location of diversifying residues and functional residues in the 3C protease. Three different views of diversifying residues in the HRV2 3C protease relative to protease active site residues (blue; (Matthews et al., 1999)) and residues implicated in RNA binding and VPg binding (green; (Matthews et al., 1999). A. Relative to both protease and RNA binding/VPg interacting domain. B. Relative to RNA binding/VPg interaction domain. C. Relative to the proteolytic active site (Matthews et al., 1999). Diversifying residues are shown in red, shaded according to their corresponding dN/dS values indicated by the scale bar; yellow, diversifying residues that directly overlap functional residues.