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Figure 2 | Virology Journal

Figure 2

From: Replicative Homeostasis III: implications for antiviral therapy and mechanisms of response and non-response

Figure 2

Selective replication of fit (~consensus sequence) genomes. If high-level genomic replication by RNApol is contingent on recognition of appropriate 5'UTR sequences by RNApol (i) and full length genomic transcription (ii) and ribosomal (R) translation of functional (f) polyprotein encoding both fRNApol and fEnvelope, then replication is an extremely effective test of genomic integrity (panel A) that powerfully selects for fit genomes and self genotypes. Inappropriate 5'UTR sequences (i) or truncation of transcription (ii), or synthesis of functionally defective mutant (mt) RNApol or Envmt sequences cause inefficient or abrogated replication, powerfully selecting against defective genomes, therefore resisting EC, as well as reducing the likelihood of replicating viruses of other genotypes.

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