Figure 1

Classical patterns of HCV response to IFN/ribavirin (A), modified from [26], demonstrating virological non-response (black line ●), partial response (blue line ◆), relapse (green ▲) and sustained virological response, SVR (red ). (B) HCV RNA response to Interferon (blue line), showing the rapid reduction in HCV RNA of phase 1 clearance followed by slow steady decline typical of phase 2 clearance, and during ribavirin therapy (red lines) in 2 representative individuals (B3, B6) reported by Pawlotsky et al [78]. Note moderate decrease in HCV RNA (-1.5 logs) in B3 (▲), but preceding slight increase (to +0.17 log) and persistent increase (to +0.25 log) in B6 ().