Figure 1From: Conserved aspartic acid 233 and alanine 231 are not required for poliovirus polymerase function in repliconsLocation of mutations. Mutated residues are shown in bold type. Row A presents the wild type amino acid and nucleic acid sequence for part of motif A, starting with glutamic acid at 226 and G at nucleotide position 680 in poliovirus 3Dpol. Row B shows the mutation that was inserted to construct the mutant D233A. Row C shows the mutation A231C. Row D shows the sequence of the double mutant A231C/D233A.Back to article page