Different rates of (non-)synonymous mutations in astrovirus genes; correlation with gene function

Table 4 Integrin-binding sequence motifs in astrovirus capsid proteins

Integrin-binding sequence motifs in Astroviral capsid proteins
CorePeptide	IntegrinType	CorePeptide	IntegrinType	CorePeptide	IntegrinType
RGD	α5,8,vβ1	LDV	α4β1	NGR	RGD-like
	αvβ 3,5,6,8				low affinity
	αIIbβ3
AstroVirus	location	AstroVirus	location	AstroVirus	location
H1	VP25	H1	VP34	H1	VP34
Mink	VP34	H3	VP34	H2	VP34
Sheep	VP34	H4	VP34	H3	VP34
		H5	VP34	H4	VP34
		H6	VP34	H5	VP34
		H7	VP34	H6	VP34
		H8	VP34	H7	VP34
		Feline	VP34	H8	VP34 & VP25
		Sheep	VP34	Feline	VP34
		Turkey2	VP25	Pig	VP34
				Turkey2	VP25

Sequence motifs (in boldface) are mentioned with the specified subtypes of integrin. The presence of the RDG consensus sequence in human astrovirus serotype 1 was revealed by means of PROSITE. Other putative sequence motifs were traced by text-editing and as yet, experimental support is absent.

ISSN: 1743-422X