Table 4 Annotated candidate genes for viral defense listed alphabetically.

CXXC5

CXXC finger 5

Up in Pol-8, Vac-4, Ifn-8 and BKV

H

H

DNA binding/regulator of gene transcription

HMGB2

High-mobility group box 2

Induced by both Pol and Ifn (16 h)

H

M

DNA binding and regulation, cytokine

ITGAV

Integrin α5

Down or border line down in all experiments

M-H

L (or just below L)

Membrane protein associated with adhesion and signal transduction, virus uptake

LY6E

Lymphocyte antigen 6 complex locus E

Induced by both Pol and Ifn (8 h)

M-H

M-H

Cell surface receptor involved in defense

LZTR1

Leucine-zipper-like transcription regulator 1

Induced by both Pol and Ifn (8 h)

H

H

Transcription regulator

MATN4

Matrilin4

Up in Pol-8, Pol-16, Vac-4, Ifn-16 and BKV

M-H

M-H

Extracellular matrix adapter?

MT1L

Metallothionein 2A

Induced by both Pol and Ifn (16 h)

H

M

Metal binding/homeostasis

PKM2

Pyruvate kinase, muscle

Induced by both Pol and Ifn (8 h)

H

H

Kinase activity

RND3

Ras homolog gene family E

Induced by both Pol and Ifn (16 h)

H

M

Actin cytoskeleton

SIGLEC1

Sialoadhesin

Induced by both Pol and Ifn (8 h)

H

H

Immunoglobulin adhesion molecule on cell surface

UBC

Ubiquitin C

Induced by both Pol and Ifn (8 h)

H

H

Selective protein degradation