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Table 3 Gene ontology analyses of up-regulated genes.

From: Modulation of gene expression in a human cell line caused by poliovirus, vaccinia virus and interferon

Gene lists used for comparison

Biological process category

Number of overrepresented genes/all genes in category (p-value)

Vac-4 up-regulated

Regulation of cell proliferation GO:0042127

7/181 (0.000)

 

Positive regulation of cell proliferation GO:0008284

5/80 (0.000)

 

Wound healing GO:0042060

4/57 (0.001)

Pol-8 up-regulated

Antigen processing (GO:0030333)

3/39 (0.010)

 

Antigen presentation (GO:0019882)

3/46 (0.016)

 

Regulation of signal transduction (GO:0009966)

6/175 (0.016)

 

Regulation of I-kappaB kinase/NF-kappaB cascade (GO:0043122)

4/85 (0.017)

 

Response to extracellular stimulus (GO:0009991)

2/18 (0.018)

Pol-16 up-regulated

DNA replication (GO:0006260)

9/171 (0.000)

 

Response to wounding (GO: 0009611)

8/213 (0.003)

 

Regulation of signal transduction (GO:0009966)

7/175 (0.004)

 

Response to stress (GO:0006950)

17/758 (0.007)

 

Regulation of MAPK activity (GO:0043405)

3/37 (0.009)

 

RNA modification (GO:009451)

2/16 (0.0015)

 

Cell proliferation (GO:0008283)

11/433 (0.017)

  1. The cells were incubated with poliovirus (Pol) for 8 or 16 h, or with vaccinia virus (Vac) for 4 h prior to microarray examination. Lists of up-regulated genes were compared with the lists of all the genes expressed in that experiment, using the Target-master statistical test available under GeneTools [37]. Only the more significant and more relevant results are presented. The total number of annotated, expressed genes was 10195.