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Table 2 rDEN1/4 chimeric virus replication in SCID-HuH-7 mice.

From: Vaccine candidates for dengue virus type 1 (DEN1) generated by replacement of the structural genes of rDEN4 and rDEN4Δ30 with those of DEN1

Virus1 No. mice Peak virus titer (log10 PFU/ml ± SE) Fold reduction from wild type DEN1
DEN1 Puerto Rico/942 18 6.6 ± 0.1 --
rDEN1/4(CME) 8 5.0 ± 0.43 40
rDEN1/4Δ30(CME) 7 4.4 ± 0.43 159
rDEN1/4(ME) 9 6.8 ± 0.3 -2
rDEN1/4Δ30(ME) 7 5.2 ± 0.53 25
  1. 1 Groups of SCID-HuH-7 mice were inoculated into the peritoneal tumor with 4.0 log10 PFU of the indicated virus. Serum was collected on day 7, and virus titer was determined in Vero cells.
  2. 2 Data combined from 2 experiments.
  3. 3 Significant reduction compared to wild type DEN1 (Tukey post-hoc test, P < 0.05).