From: Vaccine candidates for dengue virus type 1 (DEN1) generated by replacement of the structural genes of rDEN4 and rDEN4Δ30 with those of DEN1
Virus1
No. mice
Peak virus titer (log10 PFU/ml ± SE)
Fold reduction from wild type DEN1
DEN1 Puerto Rico/942
18
6.6 ± 0.1
--
rDEN1/4(CME)
8
5.0 ± 0.43
40
rDEN1/4Δ30(CME)
7
4.4 ± 0.43
159
rDEN1/4(ME)
9
6.8 ± 0.3
-2
rDEN1/4Δ30(ME)
5.2 ± 0.53
25