Table 1 Nonsynonymous adventitious mutations identified in rDEN1/4 chimeric viruses after passage in Vero cells

rDEN1/4(CME)

NS4B

7134

A → G

102

Thr → Ala

NS4B

7156

U → C

109

Val → Ala

rDEN1/4Δ30(CME)

NS2B

4269

A → G

45

Ser → Gly

NS4B

7132

C → U

101

Pro → Leu

rDEN1/4(ME)

NS4B

7162

U → C

112

Leu → Ser

rDEN1/4Δ30(ME)

prM

603

C → G

55

Arg → Gly

NS4B

7182

G → C

119

Gly → Arg

3' UTR

10471

G insertion

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