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Table 1 Nonsynonymous adventitious mutations identified in rDEN1/4 chimeric viruses after passage in Vero cells

From: Vaccine candidates for dengue virus type 1 (DEN1) generated by replacement of the structural genes of rDEN4 and rDEN4Δ30 with those of DEN1

Virus Gene/region Nucleotide Amino acid
   Number1 Change Number2 Change
rDEN1/4(CME) NS4B 7134 A → G 102 Thr → Ala
  NS4B 7156 U → C 109 Val → Ala
rDEN1/4Δ30(CME) NS2B 4269 A → G 45 Ser → Gly
  NS4B 7132 C → U 101 Pro → Leu
rDEN1/4(ME) NS4B 7162 U → C 112 Leu → Ser
rDEN1/4Δ30(ME) prM 603 C → G 55 Arg → Gly
  NS4B 7182 G → C 119 Gly → Arg
  3' UTR 10471 G insertion -- --
  1. 1 Nucleotide numbering is from 5' genome end.
  2. 2 Amino acid numbering is according to position in respective protein product.