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Table 3 Coreceptor usage by HIV-1 subtype C chimeras in U373-MAGI-CCR5 and U373-MAGI-CXCR4 cell lines.

From: Role of HIV-1 subtype C envelope V3 to V5 regions in viral entry, coreceptor utilization and replication efficiency in primary T-lymphocytes and monocyte-derived macrophages

 

MAGI-CCR5

MAGI-CXCR4

 

Infection counts →

5000

10000

5000

10000

Phenotype from MT-2

CHIMERA_

No. of blue cells

No. of blue cells

 

171

21

99

-

-

NSI

173

23

92

-

-

NSI

182

9

18

-

-

NSI

183

7

12

-

-

NSI

221A

0

2

-

-

NSI

282

9

30

-

-

NSI

284

2

6

-

-

NSI

331

13

31

-

-

NSI

334

1

2

-

-

NSI

452

23

65

-

-

NSI

512

1

3

-

-

NSI

514

1

4

-

-

NSI

639

1

2

-

-

NSI

1011

11

26

-

-

NSI

1014

16

33

-

-

NSI

2099 (B-R5)

8

19

-

-

NSI

2101 (B-X4/R5)

5

10

10

21

SI

3041 (C-R5)

7

34

-

-

NSI

5441 (C-X4)

-

-

23

38

SI

  1. NSI – non-syncytium inducing, SI – syncytium inducing, - indicate no entry due to lack of blue cells.
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Virology Journal

ISSN: 1743-422X