Table 8 mIMRs and rdIMRs that are ≥66% symmetric
mIMR DNA | mIMR AA | Protein function | rdIMR AA | ||||
|---|---|---|---|---|---|---|---|
len | begin | end | begin | end | begin | end | |
37 | 1158 | 1194 | 386 | 398 | 1st cys-his box | ||
37 | 1314 | 1350 | 438 | 450 | p1-p6 cleavage site F449..L450 | 440 | 445 |
36 | 1087 | 1122 | 362 | 374 | p2 helix, most of p2 A364..M377 | 364 | 373 |
36 | 1349 | 1384 | 450 | 461 | L domain P455..P459 | 448 | 456 |
30 | 74 | 103 | 25 | 34 | residues essential to binding to cell membrane | 25 | 36 |
28 | 1302 | 1329 | 434 | 443 | most of p1 F433..F448 | 436 | 442 |
27 | 17 | 43 | 6 | 14 | myristoylation | 8 | 13 |
26 | 562 | 587 | 187 | 196 | bridges CA H3 and CA H4 helices | 189 | 195 |
25 | 322 | 346 | 107 | 115 | part of MA H5 helix T97..A120 | 107 | 113 |
25 | 478 | 502 | 159 | 167 | bridges CA H1 and CA H2 helices | ||
25 | 734 | 758 | 245 | 253 | bridges CA H6 helix and downstream B-sheet | ||
25 | 930 | 954 | 310 | 318 | CA H9 helix, endocytosis signal T311..Q324 | 310 | 318 |
25 | 1022 | 1046 | 341 | 349 | CA H11 helix L343..C350 | 343 | 351 |
25 | 1404 | 1428 | 468 | 476 | T471A mutation leads to incomplete separation from host cell membrane | ||
24 | 356 | 379 | 119 | 126 | labile structure at end of MA | 123 | 128 |
24 | 838 | 861 | 279 | 287 | required for dimer interface | 278 | 284 |
24 | 1146 | 1169 | 382 | 390 | g helix, near start p7 | ||
23 | 772 | 794 | 257 | 265 | CA H7, potential NEC cleavage site | 256 | 268 |
23 | 1189 | 1211 | 396 | 404 | 1st cys-his box | ||
22 | 1253 | 1274 | 418 | 425 | 2cd cys-his box | 416 | 427 |
21 | 1 | 21 | 0 | 7 | minimum signal required for myristoylation | 0 | 7 |
21 | 268 | 288 | 89 | 96 | loop with highly variable charge btwn MA H4-H5 | 90 | 100 |
21 | 361 | 381 | 120 | 127 | near end of MA | 123 | 128 |
21 | 1238 | 1258 | 413 | 419 | 2cd cys-his box C412..H421 | 406 | 421 |
21 | 1274 | 1294 | 425 | 431 | ends at p7-p1 cleavage site N432..F433 | 426 | 433 |
20 | 990 | 1009 | 330 | 336 | CA H10 helix, endocytosis signal P328..L337 | 426 | 433 |
19 | 63 | 81 | 21 | 27 | basic residues essential to binding P23..H33 | 23 | 33 |
19 | 159 | 177 | 53 | 59 | MA H3 helix, mutations affect virus assembly | 51 | 57 |
19 | 192 | 210 | 64 | 70 | MA H3 helix, mutations affect virus assembly | 62 | 71 |
19 | 305 | 323 | 102 | 108 | part of MA H5 helix, potential PDZ domain binding | ||
19 | 956 | 974 | 319 | 325 | CA H9 helix, endocytosis signal Q311..Q324 | 316 | 323 |
19 | 1060 | 1078 | 353 | 359 | G-rich segment at end CA | ||
19 | 1427 | 1445 | 476 | 482 | end of Gag-PolTF | 476 | 481 |
18 | 468 | 485 | 156 | 162 | CA H1 helix | ||
18 | 541 | 558 | 180 | 186 | CA H3 helix, D184 essential to mature capsid | ||
18 | 886 | 903 | 295 | 301 | MHR | 299 | 306 |
18 | 919 | 936 | 306 | 312 | deletion causes major defect in particle formation | 304 | 310 |
18 | 956 | 973 | 319 | 324 | CA H9 helix, endocytosis signal T311..Q324 | 316 | 323 |
18 | 1389 | 1406 | 463 | 469 | ubiquitin-gag conjugates found L449..Q500 | 460 | 470 |
18 | 1461 | 1478 | 487 | 493 | vpr packaging L489..F493 | 487 | 493 |