Table 7 MIMRs ≥ 33% begin and end at cleavage sites (bold) and sites that have related functions in the translated protein
DNA mIMR | len | protein | protein function | ||
|---|---|---|---|---|---|
begin..end | begin..end | ||||
1-atg..tga-704 | 704 | begin | MA, | M-1 | start MA |
end | CA, | D-235 | CypA binding site – CA uncoating exposed loop virion core surface | ||
9-gag..gag-778 | 770 | begin | MA, | R-4 | min myristoylation signal |
end | CA, | E-260 | H7, largest component viral core | ||
35-aat..taa-811 | 777 | begin | MA, | E-12 | AP-3 binding |
calmodulin binding | |||||
plasma membrane binding | |||||
end | CA, | N-271 | H7, largest component viral core | ||
43-cga..tgc-1135 | 1093 | begin | MA, | R-15 | AP-3 binding |
calmodulin binding | |||||
plasma membrane binding | |||||
end | p2, | Q-379 | p2-NC cleavage site +1AA stage 1 Gag & Gag-Pol | ||
153-aga..gga-1228 | 1076 | begin | MA, | E-52 | -2AA essential to trimerization & virus assembly |
end | NC, | K-410 | motif crucial to NC-RT binding | ||
302-tag..gct-1293 | 992 | begin | MA, | L-101 | start, H5 helix related to viral entry |
end | NC, | A-431 | NC-p1 cleavage Gag | ||
NC-GagTF cleavage Gag-Pol | |||||
337-aaa..taa-1459 | 1123 | begin | MA, | K-113 | nuclear localization signal |
end | p6, | F-487 | end GagTF | ||
360-tga..aat-1501 | 1142 | begin | MA, | D-121 | end, H5 helix related to viral entry |
end | p6, | $-501 | end Gag (end p6) | ||
400-ata..taa-1503 | 1104 | begin | MA, | I-134 | MA-CA cleavage + 1AA Gag & Gag-Pol |
end | p6, | $-501 | end Gag (end p6) |