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Figure 3 | Virology Journal

Figure 3

From: Imperfect DNA mirror repeats in the gag gene of HIV-1 (HXB2) identify key functional domains and coincide with protein structural elements in each of the mature proteins

Figure 3

The largest mIMR in the nucleocapsid spans the two Cys-His boxes [NCBI:1F6U [18]]. Figure 3A illustrates the largest mIMR in the nucleocapsid – #6-gag. This mIMR spans both zinc knuckles and the spacer between them. Each of the next largest mIMRs in the NC, translates one of the Cys-His boxes. Figure 3B illustrates the first Cys-His box. Figure C (same polar orientation as A and B, but rotated) illustrates the two longest rdIMRs in Gag that occur in the nucleocapsid – $1-gag and $4-gag – which overlap; within the overlap region (in purple) two amino acids bind the zinc ion [19].

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Virology Journal

ISSN: 1743-422X