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Table 1 Infectiviy of mutant 16PVs

From: Thiol-reactive reagents inhibits intracellular trafficking of human papillomavirus type 16 pseudovirions by binding to cysteine residues of major capsid protein L1

 

L1 in PV stock

Infectious units

 

ng of L1/μl

%

units/μg of L1

%

SD

WT

82.0

100

1.77.E+05

100

17.5

C102A

29.3

35.7

1.05.E+05

59.3

1.40

C146A

54.9

66.9

1.64.E+05

92.4

3.37

C157A

3.46

4.22

8.60.E+04

48.1

2.04

C161A

ND

-

NT

-

-

C185A

33.8

41.2

1.62.E+05

91.4

3.86

C225A

81.2

99.0

2.82.E+05

159

4.46

C229A

8.53

10.4

9.60.E+04

54.6

5.59

C324A

5.85

7.14

8.50.E+04

50.2

2.47

C345A

44.3

54.0

3.30.E+05

187

4.03

C379A

13.1

16.0

1.62.E+05

91.4

4.43

  1. ND: not detected NT: not tested