Differences in global gene expression profiles between ethanol-induced (Class A) cirrhotic tissue versus HCV (Class A, B, C) and ethanol (Class B and C)-induced cirrhotic tissue. Expression profiles of genes differentially expressed in early ethanol-related cirrhosis versus all other samples; as identified by ANOVA. Each column represents gene expression data from an individual experiment comparing cirrhotic and normal liver and the cluster represents genes that showed a >2-fold change (P value < 0.05) in at least 3 of 15 experiments. See legend of Fig. 1 for details on clustering and the applied color scheme. Refer to Supplementary Table 3 for names of genes represented in this figure.