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Figure 2 | Virology Journal

Figure 2

From: Distinct cellular responses differentiating alcohol- and hepatitis C virus-induced liver cirrhosis

Figure 2

Differences in global gene expression profiles between HCV and ethanol-associated cirrhotic liver tissue. A. Expression of genes associated with IFN response. HCV- and EtOH-associated cirrhosis samples were clustered based on the expression of IFN-related genes that were at least 2-fold regulated with a P value ≤ 0.05 in at least 3 of 15 experiments, comparing cirrhotic tissue to a normal liver reference. See legend of Fig. 1 for details on clustering, the applied color scheme for the fold changes in the mRNA levels, and experiment representation. B. Expression of genes associated with lymphocyte activation and proliferation. Cirrhotic samples were again clustered based on the expression of lymphocyte-related genes that were at least 2-fold regulated with a P value ≤ 0.05 in at least 3 of 15 experiments comparing cirrhotic tissue to a normal liver reference. See legend of Fig. 1 for details on clustering, the applied color scheme for the fold changes in the mRNA levels, and experiment representation. See Supplementary Table 1 for a list of gene names represented in Figure 2B.

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