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Figure 2 | Virology Journal

Figure 2

From: Porcine reproductive and respiratory syndrome virus (PRRSV) infection spreads by cell-to-cell transfer in cultured MARC-145 cells, is dependent on an intact cytoskeleton, and is suppressed by drug-targeting of cell permissiveness to virus infection

Figure 2

Effects of AK-2 and IFN-γ on PRRSV replication in MARC-145 cells as determined by flow cytometry. A. Control 24 h p.i. with PRRSV; B. AK-2 pretreatment, 24 h p.i. with PRRSV; C. IFN-γ pretreatment, 24 h p.i. with PRRSV; D. AK-2 pretreatment, 42 h p.i. with PRRSV; E. Control 46 h p.i. with PRRSV; F. AK-2 started at 18 h p.i. (delayed); G. IFN-γ started at 18 h p.i. (delayed); H. AK-2 and IFN-γ in combination, started at 18 h p.i.; I & J. IFN-γ-pretreatment effects on primary (I) and secondary (J) response PRRSV antigen detection. The percentage of PRRSV antigen-positive cells is shown in the lower right quadrant for each graph.

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