Genome map of VACV-DUKE. Predicted genes are numbered and represented by colored arrows (green: structure and assembly; light blue: RNA metabolism; dark blue: DNA metabolism; dark purple: host range; pink: immunomodulators or virulence factors; black: unknown function; red staggered: fragmented orthologs of ORFs present in other OPVs; red straight arrow: truncated orthologs of ORFs present in other OPVs). Open arrowheads indicate an ORF is split over 2 lines of the diagram. Scale is shown in kb. Thick black lines represent the ITRs.