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Table 1 Comparison of the growth properties of eight different mutants in primary human foreskin fibroblasts (HFFs) and cultured human gingival tissues (Gingival tissues) with those of the parental TowneBAC.

From: Infection of human cytomegalovirus in cultured human gingival tissue

Mutants HFFs Gingival Tissue
TowneBAC +++ +++
ΔUL13 +++ ++
ΔUL24 +++ +++
ΔUL25 +++ +++
ΔUL108 +++ +++
ΔUS18 +++ +
ΔUS20 +++ +++
ΔUS29 +++ +++
ΔRL9 +++ +++
  1. Cells (1 × 106 HFFs) or tissues were infected with each virus at 2 × 104 PFU and at 10 days post-infection, cells and tissues were harvested and sonicated. The viral titers were determined by plaque assays on HFFs in triplicate experiments [46]. +++, titer similar to that of TowneBAC; ++, titer about 10 times lower than that of TowneBAC; +, titer at least 100 times lower than that of TowneBAC.