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Figure 3 | Virology Journal

Figure 3

From: HIV-1 designed to use different tRNAGln isoacceptors prefers to select tRNAThr for replication

Figure 3

Sequence complementarity of tRNAGln and tRNAThr with mutant proviral genomes. Panel A. Sequence complementary of tRNAGln,3 with NL-4-Gln3-AC. Depicted is the predicted complementarity between the 3' terminal nucleotides and the PBS and the anticodon of tRNAGln,3 with the modified A-loop region of NL-4-Gln3-AC. Panel B. Complementarity between 3' terminal nucleotides of tRNAThr with the PBS of NL4-Gln3-AC. Nucleotide differences within the PBS and tRNAThr are underlined. The anticodon region of tRNAThr has complementarity with the modified A-loop region of NL-4-Gln3. Additional complementarity between tRNAThr and the PBS of NL-4-Gln1-AC is also shown. The single nucleotide difference between the PBS is underlined. The resulting GC pair of tRNAThr and the PBS of NL-4-Gln3-AC should be compensated for by a GU base pair. Note also the predicted complementarity between the anticodon region of tRNAThr with the modified A-loop region of NL-4-Gln1-AC.

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