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Figure 1 | Virology Journal

Figure 1

From: Use of recombinant lentivirus pseudotyped with vesicular stomatitis virus glycoprotein G for efficient generation of human anti-cancer chimeric T cells by transduction of human peripheral blood lymphocytes in vitro

Figure 1

Simplified scheme of T cell activation by A) the T cell receptor and the co-stimulatory receptor, CD28 and B) a chimeric receptor in which co-stimulation and antigen specific activation are provided by a single molecule that is not dependent on MHC-1-associated peptide presentation. *LCK is a lipid raft-associated protein that phosphorylates ITAMs of the TCR zeta chain, allowing them to bind the zeta associated protein kinase ZAP-70. LCK then also activates ZAP-70 by phosphorylation, continuing the T cell signaling cascade. [44]. While it is generally accepted that LCK is activated when CD4 or CD8 co-receptors are cross-linked with the TCR and MHC complex, it is also known that some LCK associates with CD8 in the absence of MHC [45]. It is possible that LCK activation is a function of the surrounding membrane environment rather than the clustering of co-receptors with T cell receptor and MHC [46].

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